Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HIF1A, NFKB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's disease | associated_with | disease | 0.50 |
| IL1B, TNFA, NLRP3 | co_associated_with | gene | 0.40 |
| IGFBPL1 | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| C1QA, C3, CX3CR1, CX3CL1 | co_associated_with | gene | 0.40 |
| GPR43, GPR109A | co_associated_with | gene | 0.40 |
| CLOCK, ARNTL | co_associated_with | gene | 0.40 |
| DNMT3A, HDAC1/2 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Perinatal Hypoxia-Primed Microglia Targeting | 0.548 | Alzheimer's disease | Neuroinflammation and microglial priming |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.651
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Single-cell RNA sequencing of microglial states in AD hippocampus | exploratory | Alzheimer's disease | 0.850 | 0.00 | AD mouse hippocampus | proposed | N/A |
| Network Pharmacology Analysis of Shared AD Targets | exploratory | Alzheimer's disease | 0.850 | 0.00 | Computational network analysis | proposed | N/A |
| Morphological characterization of microglial states in human brain | exploratory | Alzheimer's disease | 0.800 | 0.00 | human brain tissue | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity